What did this study find?
A 2025 systematic review of eight randomized trials covering 372 people with multiple sclerosis examined pulsed electromagnetic field treatment and mood outcomes. The review reports a consistent safety profile and describes plausible mechanisms involving neuroplasticity and neurotransmitter modulation. As a review it synthesizes existing trials rather than producing new efficacy data.
What are the details of this record?
- Full citation
- Ashrafi S, et al. Effects of PEMF therapy on fatigue, depression, and quality of life in individuals with MS: A systematic review. Archives of Neuroscience. 2025.
- Journal
- Archives of Neuroscience
- Authors
- Ashrafi S, et al.
- Study design
- Systematic review
- Sample size and population
- 372 MS patients across 8 RCTs
- Evidence grade
- Grade B on the BioReg grading scale
- Reported findings
- Systematic review of 8 RCTs with 372 participants. Demonstrates PEMF's safety profile and mechanisms for mood regulation through neuroplasticity and neurotransmitter modulation.
- DOI
- No DOI recorded
- PubMed
- Not indexed in PubMed
- Related categories
- Depression (category grade B+)
A positive PEMF study is not evidence for a specific device unless the signal parameters studied, frequency, intensity, waveform, and exposure duration, are reasonably comparable to what that device produces. Where this record does not list those parameters, the source report did not publish them. See the grading methodology. Library last reviewed 2026-08-27.